CBD and Caffeine – The Magic Duo

The most frequently consumed psychoactive drug in the world is caffeine. Caffeine in the form of coffee has been a timeless tradition. Several companies have recently added new synergistic calming ingredients to coffee like L-theanine…and now CBD.

CBD is a wonder for calming the mind and anti-inflammatory to the brain; it’s about time it becomes one with coffee – aka liquid focus. Interesting enough, the two substances go very well together!

Turns out this is the magic duo for calm, focused energy.

Interestingly enough, caffeine is metabolized by the liver enzyme pathway CYP450. We know that CBD also inhibits the CYP450 enzyme system, making the half life of caffeine longer. This can mean the effects of the caffeine will be prolonged. That can be both good and bad, depending on how sensitive you are to caffeine!

Your body has a molecule called adenosine; caffeine works because it ‘mimics’ adenosine’s action of binding to the A2a receptor. Essentially, by caffeine binding to the adenosine receptors, your body will keep adenosine around longer which promotes alertness.

Essentially when your body’s own adenosine binds to the receptor it’s calming. When adenosine cannot bind to your body’s receptors, and stays around longer and can increase your alertness and mental clarity.

CBD also can bind to this A2a receptor just like coffee can. When taking both at once, theoretically, adenosine has no chance of binding and stays around longer resulting in more sustained energy with reduction in the jittery anxiety from caffeine.

On the bright side, CBD and caffeine together will cause the boost from your morning cup of coffee to last all day instead of just a few hours. On the downside, it’s easy to overdo it and end up wide-eyed in bed when you are trying to go to sleep.

The most critical thing to mention is that CBD dosing matters. CBD must be dosed appropriately to produce the calming effect; too much may cause sedation. Working with a CBD fluent practitioner or learning about CBD dosing can help avoid this and provide all the health benefits of CBD. To learn more about CBD dosing and find your unique CBD dose talk to one of our dosing specialists at CBD Plaza. To find premium CBD products that are recommended by Dr. Amber Krogsrud, visit https://www.cbdplaza.com/dramber/.

About the Author

Dr. Amber is a Licensed Naturopathic Doctor at My Bright Wellness and Medical Director for KIYA Longevity and resides in Los Angeles, CA. She is trained in regenerative medicine, detoxification protocols, hormone testing and treatment, bioidentical hormone therapy, peptide therapy and IV nutrient therapy. She also has a practice in Redondo Beach, CA where she specializes in bioidentical hormones and peptide therapy. Dr. Amber is a member of the International Peptide Society (IPS) and has completed peptide therapy certification training through the American Academy of Anti-aging (A4M). You can find more out about the author at www.drambernd.com


Ruiz-Valdepeñas, L., Martínez-Orgado, J.A., Benito, C. et al. Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study. J Neuroinflammation 8, 5 (2011). https://doi.org/10.1186/1742-2094-8-5 https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-8-5

Yamaori, S., Maeda, C., Yamamoto, I. et al. Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids. Forensic Toxicol 29, 117–124 (2011). https://doi.org/10.1007/s11419-011-0112-7

Sumner Burstein, Cannabidiol (CBD) and its analogs: a review of their effects on inflammation, Bioorganic & Medicinal Chemistry, Volume 23, Issue 7, 2015, Pages 1377-1385, ISSN 0968-0896, https://doi.org/10.1016/j.bmc.2015.01.059.

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